Iron-Catalysed Fluoroaromatic Coupling Reactions under Catalytic Modulation with 1,2-Bis(diphenylphosphino)benzene

T. Hatakeyama, Y. Kondo, Y. Fujiwara, H. Takaya, S. Ito, E. Nakamura, M. Nakamura*
Chem. Commun. 2009, 1216–1218.  DOI: 10.1039/b820879d

Abstract: A catalytic amount of 1,2-bis(diphenylphosphino)benzene (DPPBz) achieves selective cleavage of sp3-carbon–halogen bond in the iron-catalysed cross-coupling between polyfluorinated arylzinc reagents and alkyl halides, which was unachievable with a stoichiometric modifier such as TMEDA; the selective iron-catalysed fluoroaromatic coupling provides easy and practical access to polyfluorinated aromatic compounds.

-Original Articles, Publications